This may help prevent worsening of your condition and reduce the possibility of withdrawal symptoms, including stomach cramps, anxiety, fever, nausea, runny nose, sweating, tremors, or trouble with sleeping. Using this medicine while you are pregnant may cause serious unwanted effects, including neonatal withdrawal syndrome in your newborn baby.Oct 8, 2013 · A 56-year-old patient presented to the pharmacy with a prescription for HYDROcodone bitartrate 7.5 mg and acetaminophen 750 mg after surgery.The pharmacy label on the prescription bottle dispensed to the patient read “Hydrocodone/APAP 7.5/750 mg, take one tablet by mouth every 4 to 6 hours as needed for pain.” Hydrocodone is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain. This monograph only includes information about the use of hydrocodone alone.Answers. Generally speaking hydrocodone 7.5 (Vicodin) has more narcotic in it then Tramadol 50 mgs. However, pain medications are not about strength. Instead it all comes down to which pain medication works best for you and your condition for which your taking the pain med. That is why it's best to talk to your doctor before he/she chooses a ...THSC Hydrocodone/APAP Tablet - Uses, Side Effects, and More Warnings: Hydrocodone / acetaminophen has a risk for abuse and addiction, which can lead to overdose and death. Hydrocodone/...Trouble breathing or swallowing. But hydrocodone can make you feel tired, while oxycodone is more likely to make you drowsy or constipated. Taking too much can lead to an overdose, which causes ...Feb 6, 2023 · Medications that contain hydrocodone are controlled substances. They’re considered Schedule 2 medications. Schedule 2 controlled substances have a high risk of causing dependence and misuse. This is one reason why hydrocodone should only be taken at a low dose and for the shortest amount of time possible. Schedule 2 controlled substances can ... Vicodin is a prescribed combination of hydrocodone and acetaminophen. Hydrocodone is a strong narcotic pain-reliever (analgesic) and a cough suppressant, similar to codeine. Hydrocodone blocks the receptors on nerve cells in the brain that give rise to the sensation of pain. Acetaminophen is a non-narcotic analgesic ( pain reliever) and ...The combination of hydrocodone and acetaminophen is used for pain relief. But it comes with a host of side effects, including nausea and vomiting. Learn more here.Title: Hydrocodone (Trade Names: Vicodin®, Lortab®, Lorcet-HD®, Hycodan®, Vicoprofen®) Author: DEA Diversion Control Division Keywords: Hydrocodone Vicodin Lortab Lorcet-HD Hycodan VicoprofenHydrocodone/paracetamol (also known as hydrocodone/acetaminophen) is the combination of the pain medications hydrocodone and paracetamol (acetaminophen). It is used ...abbreviation. acetaminophen used especially when combined with a prescription drug. HOW SHOULD THE TOTAL DAILY DOSE OF OPIOIDS BE CALCULATED? 1. DETERMINE. the total daily amount . Calculating morphine milligram equivalents (MME) of each opioid the patient takes. Mar 10, 2023 · Vicodin and Percocet are two powerful prescription opioid medications used to treat pain. Vicodin contains hydrocodone and acetaminophen. Percocet contains oxycodone and acetaminophen. .Read on ... Dose adjustments to hydrocodone extended-release capsules should be made in 10 mg increments every 12 hours, every 3 to 7 days. Dose adjustments to hydrocodone extended-release tablets should be made in 10 to 20 mg increments every 24 hours, every 3 to 5 days. If unacceptable side effects occur, the dose may be reduced.Vicodin is a prescribed combination of hydrocodone and acetaminophen. Hydrocodone is a strong narcotic pain-reliever (analgesic) and a cough suppressant, similar to codeine. Hydrocodone blocks the receptors on nerve cells in the brain that give rise to the sensation of pain. Acetaminophen is a non-narcotic analgesic ( pain reliever) and ... Lists the various brand names available for medicines containing hydrocodone. Find information on hydrocodone use, treatment, drug class and molecular formula.You can also always know the strengths from the label. Hydro is Hydrocodone, which is the opiate in the pill, and APAP is the Tylenol. Now the numbers are 10/325. That means 10 mg of Hydro, and 325 mg of acetaminophen. You might also see 5/500. That would be 5 mg of the Hydro and 500 mg of Tylenol. There used to be a 10/1000.May 3, 2018 · cvs.com. APAP is short for N-acetyl-para-aminophenol, better known as acetaminophen or paracetamol. The abbreviation is taken from the initials of the major chemical elements, as shown here in bold: N- a cetyl- p ara- a mino p henol. The substance belongs to a group of pain- and fever-reducing medicines called analgesics. Aug 1, 2023 · Vicodin HP. Zydone. Descriptions. Hydrocodone and acetaminophen combination is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. Aug 1, 2023 · Hydrocodone belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain. When hydrocodone is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep ... Jan 10, 2023 · Summary. The length of time that hydrocodone stays in the body varies from person to person. This is due to factors such as age, genetics, and the frequency of intake. Generally, one dose takes at ... FnL1 02 0052 01 E0FiYm90dCBMYWJvcmF0b3JpZXMLSnVs 02 aWUgU21pdGgARVBK6w== 035543 ® (No. 1949) 03-5543-R3-Rev. November, 2006 (hydrocodone bitartrate andDose adjustments to hydrocodone extended-release capsules should be made in 10 mg increments every 12 hours, every 3 to 7 days. Dose adjustments to hydrocodone extended-release tablets should be made in 10 to 20 mg increments every 24 hours, every 3 to 5 days. If unacceptable side effects occur, the dose may be reduced.Jul 31, 2023 · Usual Adult Dose for Pain. Oral tablets: Hydrocodone 5 mg-acetaminophen 325 mg per tablet. Initial dose: 1 to 2 tablets every 4 to 6 hours as needed for pain. Maximum dose: 8 tablets/24 hours. Hydrocodone 7.5 mg-acetaminophen 325 mg and Hydrocodone 10 mg-acetaminophen 325 mg per tablet: Initial dose: 1 tablet every 4 to 6 hours as needed for pain. THSC Hydrocodone/APAP Tablet - Uses, Side Effects, and More Warnings: Hydrocodone / acetaminophen has a risk for abuse and addiction, which can lead to overdose and death. Hydrocodone/...See full list on mayoclinic.org Oxycodone is semi-synthetic and is synthesized from thebaine (an opium alkaloid) and will only relieve pain, not cough. 1,12. Hydrocodone is also semi-synthetic but derived from codeine, and while more potent than codeine, still retains cough suppressant properties. It is more commonly found in combination with other nonopioid analgesics (for ...Descriptions. Hydrocodone is used to relieve pain in opioid-tolerant patients severe enough to require around-the-clock pain relief for a long period of time. It should not be used if you need pain medicine for just a short time, such as when recovering from surgery. Do not use this medicine to relieve mild pain.Answers. Generally speaking hydrocodone 7.5 (Vicodin) has more narcotic in it then Tramadol 50 mgs. However, pain medications are not about strength. Instead it all comes down to which pain medication works best for you and your condition for which your taking the pain med. That is why it's best to talk to your doctor before he/she chooses a ...Jun 5, 2023 · Common Lortab side effects include: drowsiness, headache; upset stomach, constipation; blurred vision; or. dry mouth. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Serious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders. Common Norco side effects include: drowsiness, headache; upset stomach, constipation; blurred vision; or. dry mouth.Aug 27, 2021 · Hydrocodone side effects can range from mild to severe and some can occur even when taking hydrocodone as prescribed. 3 These side effects can impact several systems in your body, including respiratory, cardiovascular, gastrointestinal, and neurologic functions. 3. Some hydrocodone side effects include: 3. Breathing problems. Aug 14, 2013 · Following hip-replacement surgery, I was given a prescription for 160 painkillers called “Hydrocodone/APAP 5-325.” I’ve taken only one tablet. What’s the street value of the remaining 159? Pill with imprint n 356 5 is White, Capsule-shape and has been identified as Acetaminophen and Hydrocodone Bitartrate 325 mg / 5 mg. It is supplied by Novel Laboratories, Inc. We would like to show you a description here but the site won’t allow us. PRECAUTIONS SECTION. General. Special Risk Patients. As with any narcotic analgesic agent, hydrocodone bitartrate and acetaminophen tablets should be used with caution in elderly or debilitated patients and those with severe impairment of hepatic or renal function, hypothyroidism, Addison’s disease, prostatic hypertrophy or urethral stricture.Title: Hydrocodone (Trade Names: Vicodin®, Lortab®, Lorcet-HD®, Hycodan®, Vicoprofen®) Author: DEA Diversion Control Division Keywords: Hydrocodone Vicodin Lortab Lorcet-HD Hycodan Vicoprofen Jan 7, 2021 · 30 mg 4-5 mg 300 mcg 90 mg Hydrocodone/APAP (Norco®) 7.5-325 mg q4h prn or Hydrocodone/APAP (Norco®) 10-325 mg q4h prn or Hydrocodone/APAP (Norco®) 7.5-325 mg (2 tab) q6h prn or Oxycodone/APAP (Percocet®) 5 mg q4h prn*** 40 mg 6 mg 400 mcg 120 mg Hydrocodone/APAP (Norco®) 10-325 mg q4h prn or Apr 9, 2021 · Dosage for moderate to severe pain. Adult dosage (ages 18 years and older and weighing at least 101 pounds [46 kg]) 5 mg or 2.5 mg hydrocodone / 300 mg or 325 mg acetaminophen: The typical dosage ... The chemical name is: 4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5). It has the following structural formula: . Acetaminophen, 4’-hydroxyacetanilide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic.Descriptions. Hydrocodone is used to relieve pain in opioid-tolerant patients severe enough to require around-the-clock pain relief for a long period of time. It should not be used if you need pain medicine for just a short time, such as when recovering from surgery. Do not use this medicine to relieve mild pain.Jan 10, 2018 · Hydrocodone has an average half-life of roughly 3.8 hours in healthy adult males. In other words, it takes 3.8 hours for the average healthy male to eliminate half of the dose of hydrocodone ... When this potent narcotic is abused, a person will experience symptoms, and concerned onlookers will see signs of that abuse. The most commonly reported physical, psychological, and behavioral signs and symptoms of hydrocodone addiction are: Slowed heart rate. Anxiety. Difficulty breathing. Depression. Feeling fearful.Vicodin HP. Zydone. Descriptions. Hydrocodone and acetaminophen combination is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time.Jul 31, 2023 · Usual Adult Dose for Pain. Oral tablets: Hydrocodone 5 mg-acetaminophen 325 mg per tablet. Initial dose: 1 to 2 tablets every 4 to 6 hours as needed for pain. Maximum dose: 8 tablets/24 hours. Hydrocodone 7.5 mg-acetaminophen 325 mg and Hydrocodone 10 mg-acetaminophen 325 mg per tablet: Initial dose: 1 tablet every 4 to 6 hours as needed for pain. Hydrocodone is a semisynthetic opioid medication that is widely used as an analgesic and antitussive. Since 2004 it has been the most commonly prescribed drug in the United States and is often misused as a drug of abuse. Hydrocodone is frequently encountered in the postmortem setting, both as a caus …Acetaminophen, 4' -hydroxyacetanilide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. It has the following structural formula: Each Hydrocodone Bitartate and Acetaminophen Tablet, USP contains: Strength. Hydrocodone Bitartrate. Acetaminophen. 2.5 mg/325 mg. 5 mg/325 mg.Oct 8, 2013 · A 56-year-old patient presented to the pharmacy with a prescription for HYDROcodone bitartrate 7.5 mg and acetaminophen 750 mg after surgery.The pharmacy label on the prescription bottle dispensed to the patient read “Hydrocodone/APAP 7.5/750 mg, take one tablet by mouth every 4 to 6 hours as needed for pain.” trembling or shaking. twitching. unable to speak. unusual bleeding or bruising. unusual tiredness or weakness. upper right abdominal or stomach pain. vomiting. yellow eyes and skin. Get emergency help immediately if any of the following symptoms of overdose occur while taking acetaminophen / hydrocodone:Hydrocodone / acetaminophen has a risk for abuse and addiction, which can lead to overdose and death. Hydrocodone/ acetaminophen may also cause severe, possibly fatal, breathing problems. To...Hydrocodone bitartrate and acetaminophen is available in liquid form for oral administration. Hydrocodone bitartrate is an opioid analgesic and occurs as fine, white crystals or as a crystalline ... Hydrocodone Bitartrate and Acetaminophen Oral Solution contains: Per 5 mL. Per 10 mL. Per 15 mL.Oxycodone is semi-synthetic and is synthesized from thebaine (an opium alkaloid) and will only relieve pain, not cough. 1,12. Hydrocodone is also semi-synthetic but derived from codeine, and while more potent than codeine, still retains cough suppressant properties. It is more commonly found in combination with other nonopioid analgesics (for ...Mar 10, 2023 · Vicodin and Percocet are two powerful prescription opioid medications used to treat pain. Vicodin contains hydrocodone and acetaminophen. Percocet contains oxycodone and acetaminophen. .Read on ... inhibitor or inducer The concomitant use of NORCO with all Cytochrome P450 3A4 inhibitors may result in an increase in hydrocodone plasma concentrations, which could increase or prolong adverse reactions and may causeWe would like to show you a description here but the site won’t allow us. Inform patients that hydrocodone bitartrate and acetaminophen tablets could cause adrenal insufficiency, a potentially life-threatening condition. Adrenal insufficiency may present with non-specific symptoms and signs such as nausea, vomiting, anorexia, fatigue, weakness, dizziness, and low blood pressure.DESCRIPTION. Hydrocodone bitartrate and acetaminophen, USP is available in tablet form for oral administration. Hydrocodone bitartrate is an opioid analgesic and occurs as fine, white crystals or as a crystalline powder.Results for "Acetaminophen and hydrocodone bitartrate" (1 - 18 of 172) 1 / 4. Jan 10, 2018 · Hydrocodone has an average half-life of roughly 3.8 hours in healthy adult males. In other words, it takes 3.8 hours for the average healthy male to eliminate half of the dose of hydrocodone ... PRECAUTIONS SECTION. General. Special Risk Patients. As with any narcotic analgesic agent, hydrocodone bitartrate and acetaminophen tablets should be used with caution in elderly or debilitated patients and those with severe impairment of hepatic or renal function, hypothyroidism, Addison’s disease, prostatic hypertrophy or urethral stricture.Common Lortab side effects include: drowsiness, headache; upset stomach, constipation; blurred vision; or. dry mouth. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.Hydrocodone is a semisynthetic opioid medication that is widely used as an analgesic and antitussive. Since 2004 it has been the most commonly prescribed drug in the United States and is often misused as a drug of abuse. Hydrocodone is frequently encountered in the postmortem setting, both as a caus …Long-term use of any opioid, such as hydrocodone, can result in serious health effects. These include cardiovascular damage, respiration difficulties, chronic constipation, other gastrointestinal issues, and hormonal fluctuations. In addition, addiction to any substance brings a range of serious effects.Apr 3, 2023 · Oxycodone is semi-synthetic and is synthesized from thebaine (an opium alkaloid) and will only relieve pain, not cough. 1,12. Hydrocodone is also semi-synthetic but derived from codeine, and while more potent than codeine, still retains cough suppressant properties. It is more commonly found in combination with other nonopioid analgesics (for ... A strong prescription pain medicine that contains an opioid (narcotic) that is used to manage pain severe enough to require an opioid pain medicine, when other pain treatments such as non-opioid pain medicines do not treat your pain well enough or you cannot tolerate them. An opioid pain medicine that can put you at risk for overdose and death.Hydrocodone has an average half-life of roughly 3.8 hours in healthy adult males. In other words, it takes 3.8 hours for the average healthy male to eliminate half of the dose of hydrocodone ...The most commonly prescribed strength of hydrocodone/APAP is 7.5/500. Dosing and Administration — For moderate to moderately-severe pain in adults, initial oral dosing is one 7.5/500 tablet of...Acetaminophen-hydrocodone oral tablet is used to treat moderate to severe pain that other treatments have not been able to relieve. Other warnings Severe allergic reaction warning: This...inhibitor or inducer The concomitant use of NORCO with all Cytochrome P450 3A4 inhibitors may result in an increase in hydrocodone plasma concentrations, which could increase or prolong adverse reactions and may cause Serious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders. Common Norco side effects include: drowsiness, headache; upset stomach, constipation; blurred vision; or. dry mouth.Official answer. Both Norco and Vicodin contain acetaminophen and hydrocodone. The difference between them comes down to the proportion of these two ingredients contained in each formulation. 1,2 Vicodin is only available as 5mg hydrocodone and 500mg acetaminophen, whereas Norco has three different strengths (5mg hydrocodone/325mg acetaminophen ...We would like to show you a description here but the site won’t allow us.Hydrocodone/paracetamol (also known as hydrocodone/acetaminophen) is the combination of the pain medications hydrocodone and paracetamol (acetaminophen). It is used ...Pill with imprint n 356 5 is White, Capsule-shape and has been identified as Acetaminophen and Hydrocodone Bitartrate 325 mg / 5 mg. It is supplied by Novel Laboratories, Inc. Feb 6, 2023 · Medications that contain hydrocodone are controlled substances. They’re considered Schedule 2 medications. Schedule 2 controlled substances have a high risk of causing dependence and misuse. This is one reason why hydrocodone should only be taken at a low dose and for the shortest amount of time possible. Schedule 2 controlled substances can ... Hydrocodone bitartrate and acetaminophen is available in liquid form for oral administration. Hydrocodone bitartrate is an opioid analgesic and occurs as fine, white crystals or as a crystalline ... Hydrocodone Bitartrate and Acetaminophen Oral Solution contains: Per 5 mL. Per 10 mL. Per 15 mL.The most commonly prescribed strength of hydrocodone/APAP is 7.5/500. Dosing and Administration — For moderate to moderately-severe pain in adults, initial oral dosing is one 7.5/500 tablet of...cvs.com. APAP is short for N-acetyl-para-aminophenol, better known as acetaminophen or paracetamol. The abbreviation is taken from the initials of the major chemical elements, as shown here in bold: N- a cetyl- p ara- a mino p henol. The substance belongs to a group of pain- and fever-reducing medicines called analgesics.Hydrocodone. and. Acetaminophen: (Anexsia, Dolacet, Lorcet, Lortab, Norco, Vicodin, Zydone) Growing Threat of Prescription Drug Abuse. Connecticut Department of ...
Aug 1, 2023 · Vicodin HP. Zydone. Descriptions. Hydrocodone and acetaminophen combination is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. . Man walking on i 8 in mission valley
M365 Pill - white capsule-shape, 15mm . Pill with imprint M365 is White, Capsule-shape and has been identified as Acetaminophen and Hydrocodone Bitartrate 325 mg / 5 mg. It is supplied by Mallinckrodt Pharmaceuticals.WARNINGS. Addiction, Abuse, and Misuse. Hydrocodone bitartrate and acetaminophen tablets contain hydrocodone, a Schedule II controlled substance. As an opioid, hydrocodone bitartrate and acetaminophen tablets expose users to the risks of addiction, abuse, and misuse [see DRUG ABUSE AND DEPENDENCE]. Dec 13, 2022 · The combination of hydrocodone and acetaminophen is used for pain relief. But it comes with a host of side effects, including nausea and vomiting. Learn more here. Common Vicodin side effects include: drowsiness, headache; upset stomach, constipation; blurred vision; or. dry mouth. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.Hydrocodone/paracetamol (also known as hydrocodone/acetaminophen) is the combination of the pain medications hydrocodone and paracetamol (acetaminophen). It is used ...Jan 10, 2018 · Hydrocodone has an average half-life of roughly 3.8 hours in healthy adult males. In other words, it takes 3.8 hours for the average healthy male to eliminate half of the dose of hydrocodone ... Title: Hydrocodone (Trade Names: Vicodin®, Lortab®, Lorcet-HD®, Hycodan®, Vicoprofen®) Author: DEA Diversion Control Division Keywords: Hydrocodone Vicodin Lortab Lorcet-HD Hycodan VicoprofenHydrocodone. and. Acetaminophen: (Anexsia, Dolacet, Lorcet, Lortab, Norco, Vicodin, Zydone) Growing Threat of Prescription Drug Abuse. Connecticut Department of ... Aug 1, 2023 · Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. But acetaminophen may cause other unwanted effects when taken in large doses, including liver damage. Apr 9, 2021 · Dosage for moderate to severe pain. Adult dosage (ages 18 years and older and weighing at least 101 pounds [46 kg]) 5 mg or 2.5 mg hydrocodone / 300 mg or 325 mg acetaminophen: The typical dosage ... Hydrocodone is an opioid painkiller and antitussive derived from morphine. It is found in products like Vicodin, Lortab, and Hycotuss. Since it is an opioid drug, hydrocodone binds to the opioid receptors in the brain, relieving pain, suppressing cough as it slows breathing rate, and leading to pleasant relaxation that triggers the brain’s reward system and can be addictive for some people.Hydrocodone Bitartrate and Acetaminophen Tablets USP 5 mg/325 mg only Code 667D00 Rev. 08/2014 BOXED WARNING Hepatotoxicity Acetaminophen has been associated with cases of acute liver Common side effects of hydrocodone and ibuprofen may include: dizziness, drowsiness; stomach pain, nausea, vomiting, heartburn, gas; constipation, diarrhea; or. headache. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.Every pregnancy starts out with a 3-5% chance of having a birth defect. This is called the background risk. It is not known if taking hydrocodone during pregnancy increases the chance of having a baby with a birth defect. Two studies reported that taking hydrocodone in the first trimester increased the chance of heart defects. Oxycodone. Mechanism of Action: Semi-synthetic opioid that binds to mu-opioid receptors in the central nervous system, inhibiting ascending pathways, decreasing perception and response to pain. Acts as CNS depressant. Onset: Initial effect – 10-15 minutes, Peak effect – 30-60 minutes, Duration – 3-6 hours. Starting Dose – 5-10mg every 4 ... Jan 31, 2023 · Norco (hydrocodone / acetaminophen) can cause extreme sleepiness and lower your ability to think, react, and focus. Don't drink alcohol or take other medications that can cause sleepiness or "brain fog" (e.g., benzodiazepines, muscle relaxants, sleep medications) with Norco (hydrocodone / acetaminophen). Doing so can worsen these side effects. Jul 14, 2018 · Answers. Generally speaking hydrocodone 7.5 (Vicodin) has more narcotic in it then Tramadol 50 mgs. However, pain medications are not about strength. Instead it all comes down to which pain medication works best for you and your condition for which your taking the pain med. That is why it's best to talk to your doctor before he/she chooses a ... Dec 13, 2022 · The combination of hydrocodone and acetaminophen is used for pain relief. But it comes with a host of side effects, including nausea and vomiting. Learn more here. Every pregnancy starts out with a 3-5% chance of having a birth defect. This is called the background risk. It is not known if taking hydrocodone during pregnancy increases the chance of having a baby with a birth defect. Two studies reported that taking hydrocodone in the first trimester increased the chance of heart defects. .